Acanthosis nigricans and multiple skin tags as cutaneous markers of insulin resistance. Systematic review
DOI:
https://doi.org/10.35381/s.v.v10i20.5193Keywords:
Acanthosis nigricans, insulin resistance, obesity, (Source: DeCS)Abstract
Objective: To analyze acanthosis nigricans and multiple skin tags as cutaneous markers of insulin resistance through a systematic review. Method: The study was structured using the PECO framework: adults aged 18 years and older; clinical presence of acanthosis nigricans, multiple skin tags, or a combination of both; absence of the corresponding sign or a lower number of lesions as a comparison; and insulin resistance. The search was conducted in PubMed/MEDLINE, Embase, Scopus, Web of Science, LILACS, and SciELO. Results: Acanthosis nigricans showed the most consistent association with metabolic indicators consistent with insulin resistance. The evidence regarding multiple skin tags and the coexistence of both signs pointed in the same direction but was more variable. Conclusion: The data showed that insulin resistance and acanthosis nigricans are more closely related. The results regarding the simultaneous presence of both signs and multiple skin tags were consistent, although more variable.
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Burke JP, Hale DE, Hazuda HP, Stern MP. Una escala cuantitativa de acantosis nigricans. [Internet]1999[citado 15 Jun 2026];22(10):1655-1659. https://doi.org/10.2337/diacare.22.10.1655
Barbato MT, Criado PR, Silva AK da, Averbeck E, Guerine MB, Sá NB de. Asociación de acantosis nigricans y verrugas con resistencia a la insulina. An Bras Dermatol [Internet].2012[citado 6 Jun 2026];87(1):97–104. https://doi.org/10.1590/S0365-05962012000100012
Köseoğlu HG, Bozca BC, Başsorgun Cİ, Sarı R, Akbaş SH, Karakaş AA. The role of insulin-like growth factor in acrochordon etiopathology. BMC Dermatol [Internet] 2020[citado 9 Jun 2026];20(1):14. https://doi.org/10.1186/s12895-020-00111-0
Álvarez-Villalobos, NA, Rodríguez-Gutiérrez, R., González-Saldivar, G., Sánchez-García, A., Gómez-Flores, M., Quintanilla-Sánchez, C., Treviño-Álvarez, AM, Mancillas-Adame, LG, & González-González, JG. Acantosis nigricans en adultos de mediana edad: un signo clínico altamente prevalente y específico de resistencia a la insulina. Rev. intern. de práct. clín. [Internte]2020[citado 4 Jun 2026];74(3), e13453. https://doi.org/10.1111/ijcp.13453
Dassanayake AS, Kasturiratne A, Niriella MA, Kalubovila U, Rajindrajith S, de Silva AP, y colaboradores. Prevalencia de Acantosis Nigricans en una población urbana de Sri Lanka y su utilidad para detectar el síndrome metabólico. Not. de investig. de BMC. [Internet]2011[citado 14 Jun 2026]; 4:25. https://doi.org/ 10.1186/1756-0500-4-25
Kong, A. S., Williams, R. L., Rhyne, R., Urias-Sandoval, V., Cardinali, G., Weller, N. F., Skipper, B., Volk, R., Daniels, E., Parnes, B., McPherson, L., & PRIME Net Clinicians. Acanthosis Nigricans: high prevalence and association with diabetes in a practice-based research network consortium--a PRImary care Multi-Ethnic network (PRIME Net) study. Journal of the American Board of Family Medicine. [Internet]2010[citado 13 Jun 2026];23(4), 476–485. https://doi.org/10.3122/jabfm.2010.04.090221
González-Saldívar, G., Rodríguez-Gutiérrez, R., Treviño-Álvarez, AM, Gómez-Flores, M., Montes-Villarreal, J., Álvarez-Villalobos, NA, Elizondo-Plazas, A., Salcido-Montenegro, A., Ocampo-Candiani, J., & González-González, JG. Acantosis nigricans en los nudillos: una herramienta clínica temprana, accesible, sencilla y sensible para predecir la resistencia a la insulina. Dermatoendocrinología. [Internet]2018[citado 19 Jun 2026];10(1), e1471958. https://doi.org/10.1080/19381980.2018.1471958
Ayaz, T., Baydur Şahin, S., & Şahin, OZ. Relación de la acantosis nigricans con el síndrome metabólico en mujeres con sobrepeso y obesidad. Síndr. metab. y trastor. relación. [Internet]2014[citado 8 Jul 2026];12(6),320–323. https://doi.org/10.1089/met.2013.0145
Tamega, A. de A., Aranha, A. M., Guiotoku, M. M., Miot, L. D., & Miot, H. A. Associação entre acrocórdons e resistência à insulina. Anais brasileiros de dermatología. [Internet]2010[citado 5 Jul 2026];85(1),25–31. https://doi.org/10.1590/s0365-05962010000100003
Sudy, E., Urbina, F., Maliqueo, M. y Sir, T. Detección de alteraciones metabólicas de glucosa/insulina en hombres con múltiples marcas en la piel del cuello. Journal der Deutschen Dermatologischen Gesellschaft. [Internet]2008[citado 15 Jun 2026];6(10),852–856. https://doi.org/10.1111/j.1610-0387.2008.06720.x
Rasi, A., Soltani-Arabshahi, R., & Shahbazi, N. Skin tag as a cutaneous marker for impaired carbohydrate metabolism: a case-control study. International journal of dermatology[Internet] 2007[citado 19 Jun 2026];46(11), 1155–1159. https://doi.org/10.1111/j.1365-4632.2007.03287.x
Sari, R., Akman, A., Alpsoy, E., & Balci, MK. El perfil metabólico en pacientes con verrugas cutáneas. Medicina clínica y experimental[nternet]2010[citado 22 Jun 2026];10(3),193–197. https://doi.org/10.1007/s10238-009-0086-5
Singh, SK, Agrawal, NK y Vishwakarma, AK. Asociación de acantosis nigricans y acrocordón con resistencia a la insulina: un estudio transversal hospitalario del norte de la India. Indian journal of dermatology[Internet]2020[citado 17 Jun 2026];65(2),112-117. https://doi.org/10.4103/ijd.IJD_646_18
Saxena, A., Tiwari, P., Gora, A., Sharma, B., Mandia, R., Gupta, S., Dhakar, A., Lamoria, R. K., Choudhary, P., & Mathur, S. K. Cutaneous signs of insulin resistance with central obesity: insights into adipocentric metabolic dysfunction in South Asians. Frontiers in clinical diabetes and healthcare[Internet]2025[citado 11 Jun 2026];6,1691675. https://doi.org/10.3389/fcdhc.2025.1691675
Dixit S, Chandra A, Kariwala P, Sachan B, Singh BP, Pathak A, y colaboradores. Utility of “Acanthosis Nigricans” and “Skin Tags” as a screening tool for risk of developing noncommunicable diseases: a cross-sectional study at a health facility in Lucknow, India. Ann Afr Med.[Internet]2024[citado 16 jun 2026;23(1):29-35. https://doi.org/10.4103/aam.aam_90_23
Philip NE, Girisha BS, Shetty S, Pinto AM, Noronha TM. Estimation of metabolic syndrome in acanthosis nigricans: a hospital-based cross-sectional study. Indian J Dermatol. [Internet]2022[citado 12 Jun 2026];67(1):92. https://doi.org/10.4103/ijd.ijd_442_21
Choudhary S, Srivastava A, Saoji V, Singh A, Verma I, Dhande S. Association of acanthosis nigricans with metabolic syndrome: an analytic cross-sectional study. An Bras Dermatol. [Internet]2023[citado 25 Jun 2026];98(4):460-465. https://doi.org/10.1016/j.abd.2022.07.006
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, y colaboradores. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. [Internet]2021[citado 23 Jun 2026];372: n71. https://doi.org/10.1136/bmj.n71
Koç Yıldırım S, Erbağcı E, Demirel Öğüt N. Evaluation of the relationship between clinical features of acrochordons and metabolic syndrome components: prospective cross-sectional study. Turkiye Klinikleri J Dermatol. [Internet] 2026[citado 29 Jun 2026];36(1):8-14. https://doi.org/10.5336/dermato.2025-110831
Banti S, Sumathy TK, Pramila K. Insulin resistance in various grades of acanthosis nigricans. Acta Dermatovenerol Alp Pannonica Adriat. [Internet] 2022[citado 18 Jun 2026];31(3):101-104. https://doi.org/10.15570/actaapa.2022.15
Shah VH, Rambhia KD, Mukhi JI, Singh RP, Kaswan P. Clinico-investigative study of facial acanthosis nigricans. Indian Dermatol Online J. [Internet]2022[citado 9 May 2026];13(2):221-228. https://doi.org/10.4103/idoj.IDOJ_855_20
Narayana Rao T, Gopal KVT, Chennamsetty K, Velapati STR, Ananditha K, Adapa PS. Clinical features, investigative profile and association with metabolic syndrome in facial acanthosis nigricans: a case-control study in Indian patients. Indian J Postgrad Dermatol. [Internet]2024[citado 21 Jun 2026];2(2):69-73. https://doi.org/10.25259/IJPGD_30_2024
Vishwanath K, David BG, Manobalan K, Vijay V, Dinesh I, Singh Y. A clinico-investigative study of facial acanthosis nigricans at a tertiary care centre in Puducherry. Pigment Int.[Internet]2026[citado 17 Jun 2026];13(1):40-45. https://doi.org/10.4103/pigmentinternational_79_24
Maaran AT, Prathiba P. Acanthosis nigricans and skin tags as markers of insulin resistance in non-diabetic obese individuals. J Evid Based Med Healthc. [Internet]2020[citado 4 Jul 2026];7(6):270-274. https://doi.org/10.18410/jebmh/2020/57
Sureja JB, Sureja RB, Pipalia MR, Sureja BR. Comparative study of insulin resistance markers in patients with acanthosis nigricans versus obese controls. Int J Acad Med Pharm.[Internet]2025[citado 28 Jun 2026];7(4):1244-1247. https://doi.org/10.47009/jamp.2025.7.4.235
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