Bacterial vaginosis in women in fertile age: A perspective to analyze

Authors

DOI:

https://doi.org/10.35381/s.v.v3i6.419

Keywords:

Bacterial vaginosis, Childbearing age, Polybacterial disease, STIs, Risk factors.

Abstract

Bacterial vaginosis (BV) is a type of vaginal infection caused by the normal microbiota of the vagina being replaced by Gram negative or Gram bacteria, strict or facultative anaerobes that alter the natural balance and produce change in the microflora of the vagina. Women of childbearing age are more likely to develop BV; however, this infection can affect women of any age. While the cause is not fully understood, certain activities, such as having unprotected sex or having frequent vaginal cleansing, increase the risk of infection. The disease can occur asymptomatically or with leucorrhoea and vulvar burning, in some patients it can cause important obstetric and gynecological complications. The physical-chemical and microbiological conditions of the vagina have a decisive impact on aspects such as conception, the ability to maintain a fetus at term, the risk of acquisition of sexually transmitted infections (STIs), including HIV and in the psyche and quality of life of women, especially in reproductive age; This is why the purpose of this review is to provide information that clearly discusses the etiology of BV, and especially its association with biological risk in women of childbearing age.

Downloads

Download data is not yet available.

References

Srinivasan S, Fredricks DN. The Human Vaginal Bacterial Biota and Bacterial Vaginosis. Interdisciplinary Perspectives on Infectious Diseases. 2008;1-22.

Puentes EM, Enríquez B, Jiménez MC y López P. Comportamiento del Síndrome de flujo vaginal en el Consultorio 16, Policlínico Párraga. Rev Cubana Obstet Ginecol. 2009;35(3):1-14.

Livengood CH. Bacterial Vaginosis: An Overview for 2009. Rev Obstet Gynecol. 2009;2(1):28-37.

Zongxin L, Jianming K, Fang L, Haibin Z, Xiaoyi C, Yuezhu W, et al. Molecular analysis of the diversity of vaginal microbiota associated with bacterial vaginosis. BMC Genomics. 2010; 11:488.

Verstraelen H, Verhelst R, Claeys G, De Backer E, Temmerman M, Vaneechoutte M. Longitudinal analysis of the vaginal microflora in pregnancy suggests that L. crispatus promotes the stability of the normal vaginal microflora and that L. gasseri and/or L. iners are more conducive to the occurrence of abnormal vaginal microflora. BMC Microbiology. 2009; 9:116.

Cauci S, Guaschino S, De Aloysio D, Driussi S, De Santo D, Penacchioni P y colaboradores. Interrelationships of interleukin-8 with interleukin-1beta and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women. Mol Hum Reprod, 2013;9:53-8.

Amsel R, Totten P, Spiegel C, Chen K, Eschenbach D, Holmes K. Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med 1983; 74 (1): 14-22.

Nugent R, Krohn M, Hillier S. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol 1991; 29 (2): 297-301.

Reza M, Novak RM, Lurain N, Sha BE, Graham P, Spear GT. Induction of Tumor Necrosis Factor Alpha Secretion and Toll-Like Receptor 2 and 4 mRNA Expression by Genital Mucosal Fluids from Women with Bacterial Vaginosis. JID. 2015; 91:1913-1921.

Verstraelen H, Verhelst R, Vaneechoutte M, Temmerman M. The epidemiology of bacterial vaginosis in relation to sexual behaviour. BMC Infectious Diseases. 2010; 10:81.

Navarrete P, Dominguez M, Zmelman Z. Evaluación de los criterios de Nugent y Amsel para el diagnóstico de vaginosis bacteriana. Rev med. Chile 2000, vol.128: 767-771.

Lillo g, Lizama I, Sandra C, Martinez J. Diagnóstico de vaginosis bacteriana en un consultorio de planificación familiar de la región metropolitana, Chile. Rev Chil. Infectol. 2010, vol.27(3):199-203.

Bautista Ch, Wurapa E, Sateren W, Morris S, Hollingsworth B, Sanchez JL. Bacterial vaginosis: a synthesis of the literature on etiology, prevalence, risk factors, and relationship with chlamydia and gonorrhea infections. Mil Med Res. 2016; 3: 4. doi:10.1186/s40779-016-0074-5

Livengood CH. Bacterial vaginosis: an overview for 2009. Rev Obstet Gynecol. 2009; 2:28–37.

Schwebke JR, Muzny CA, Josey WE. Role of Gardnerella vaginalis in the pathogenesis of bacterial vaginosis: a conceptual model. J Infect Dis. 2014; 210:338–43. doi: 10.1093/infdis/jiu089.

Martin DH. The microbiota of the vagina and its influence on women’s health and disease. Am J Med Sci. 2012; 343:2–9. doi: 10.1097/MAJ.0b013e31823ea228.

Rubins A. Bacterial Vaginosis. In: Gross G, Tyring SK, editors. Transmitted Infections and Sexually Transmitted Diseases Sexually. Berlin: Springer; 2011. pp. 203–206.

Kenyon C, Colebunders R, Crucitti T. The global epidemiology of bacterial vaginosis: a systematic review. Am J Obstet Gynecol. 2013; 209:505–23. doi: 10.1016/j.ajog.2013.05.006

Kenyon CR, Colebunders R. Strong association between the prevalence of bacterial vaginosis and male point-concurrency. Eur J Obstet Gynecol Reprod Biol. 2014; 172:93–96. doi: 10.1016/j.ejogrb.2013.10.011.

Ibrahim SM, Bukar M, Galadima GB, Audu BM, Ibrahim HA. Prevalence of bacterial vaginosis in pregnant women in Maiduguri. North-Eastern Nigeria Niger J Clin Pract. 2014; 17:154–8. doi: 10.4103/1119-3077.127424.

Mengistie Z, Woldeamanuel Y, Asrat D, Adera A. Prevalence of bacterial vaginosis among pregnant women attending antenatal care in Tikur Anbessa University Hospital, Addis Ababa, Ethiopia. BMC Res Notes. 2014; 7:822. doi: 10.1186/1756-0500-7-822.

Lallar M, Nanda S, Nandal R. Lower Genital Tract Infections in HIV-Infected Women: Can We Afford to Miss? J Obstet Gynaecol India. 2015; 65:45–9. doi: 10.1007/s13224-014-0604-6.

Ghiasi M, Fazaeli H, Kalhor N, Sheykh-Hasan M, Tabatabaei-Qomi R. Assessing the prevalence of bacterial vaginosis among infertile women of Qom city. Iran J Microbiol. 2014; 6:404–408.

Gergova RT, Strateva TV, Mitov IG. Gardnerella vaginalis-associated bacterial vaginosis in Bulgarian women. Braz J Infect Dis. 2013; 17:313–318. doi: 10.1016/j.bjid.2012.10.026.

Durugbo II, Nyengidiki TK, Bassey G, Wariso KT. Bacterial vaginosis among women with tubal factor infertility in Nigeria. Int J Gynaecol Obstet. 2015; 131:133–136. doi: 10.1016/j.ijgo.2015.05.031.

Vodstrcil LA, Walker SM, Hocking JS, Law M, Forcey DS, Fehler G. Incident bacterial vaginosis (BV) in women who have sex with women is associated with behaviors that suggest sexual transmission of BV. Clin Infect Dis. 2015; 60:1042–53.

Verstraelen H, Verhelst R, Vaneechoutte M, Temmerman M. The epidemiology of bacterial vaginosis in relation to sexual behaviour. BMC Infect Dis. 2010; 10:81. doi: 10.1186/1471-2334-10-81.

Jespers V, Crucitti T, Menten J, Verhelst R, Mwaura M, Mandaliya K. Prevalence and correlates of bacterial vaginosis in different sub-populations of women in sub-saharan africa: A cross-sectional study. PLoS One. 2014;9 doi: 10.1371/journal.pone.0109670.

Berg RC, Underland V, Odgaard-Jensen J, Fretheim A, Vist GE. Effects of female genital cutting on physical health outcomes: a systematic review and meta-analysis. BMJ Open. 2014;4 doi: 10.1136/bmjopen-2014-006316.

Guédou FA, Van Damme L, Deese J, Crucitti T, Becker M, Mirembe F. Behavioural and medical predictors of bacterial vaginosis recurrence among female sex workers: longitudinal analysis from a randomized controlled trial. BMC Infect Dis. 2013; 13:208. doi: 10.1186/1471-2334-13-208.

Taylor BD, Darville T, Haggerty CL. Does bacterial vaginosis cause pelvic inflammatory disease? Sex Transm Dis. 2013; 40:117–22.

Li XD, Wang CC, Zhang XJ, Gao GP, Tong F, Li X. Risk factors for bacterial vaginosis: results from a cross-sectional study having a sample of 53,652 women. Eur J Clin Microbiol Infect Dis. 2014; 33:1525–32. doi: 10.1007/s10096-014-2103-1. [PubMed] [Cross Ref]

Marconi C, Duarte MT, Silva DC, Silva MG. Prevalence of and risk factors for bacterial vaginosis among women of reproductive age attending cervical screening in southeastern Brazil. Int J Gynaecol Obstet. 2015; 131:137–41. doi: 10.1016/j.ijgo.2015.05.016.

Vodstrcil LA, Hocking JS, Law M, Walker S, Tabrizi SN, Fairley CK. Hormonal contraception is associated with a reduced risk of bacterial vaginosis: a systematic review and meta-analysis. PLoS One. 2013;8 doi: 10.1371/journal.pone.0073055.

Guédou FA, Van Damme L, Deese J, Crucitti T, Becker M, Mirembe F. Behavioural and medical predictors of bacterial vaginosis recurrence among female sex workers: longitudinal analysis from a randomized controlled trial. BMC Infect Dis. 2013; 13:208. doi: 10.1186/1471-2334-13-208.

Bilardi JE, Walker S, Temple-Smith M, McNair R, Mooney-Somers J, Bellhouse C, et al. The burden of bacterial vaginosis: women’s experience of the physical, emotional, sexual and social impact of living with recurrent bacterial vaginosis. PLoS One. 2013;8 doi: 10.1371/journal.pone.0074378

Cherpes TL, Hillier SL, Meyn LA, Busch JL, Krohn MA. A delicate balance: risk factors for acquisition of bacterial vaginosis include sexual activity, absence of hydrogen peroxide-producing lactobacilli, black race, and positive herpes simplex virus type 2 serology. Sex Transm Dis. 2008; 35:78–83. doi: 10.1097/OLQ.0b013e318156a5d0.

Marrazzo JM, Thomas KK, Agnew K, Ringwood K. Prevalence and risks for bacterial vaginosis in women who have sex with women. Sex Transm Dis. 2010; 37:335–9.

Muzny CA, Austin EL, Harbison HS, Hook EW., 3rd Sexual partnership characteristics of African American women who have sex with women; impact on sexually transmitted infection risk. Sex Transm Dis. 2014; 41:611–7. doi: 10.1097/OLQ.0000000000000194.

Ferreira CS, Marconi C, Parada CM, Duarte MT, Gonçalves AP, Rudge MV, et al. Bacterial vaginosis in pregnant adolescents: proinflammatory cytokine and bacterial sialidase profile. Cross-sectional study. Sao Paulo Med J. 2015;133(6):465–70. doi: 10.1590/1516-3180.2014.9182710.

Vasilevsky S, Greub G, Nardelli-Haefliger D, Baud D. Genital Chlamydia trachomatis: understanding the roles of innate and adaptive immunity in vaccine research. Clin Microbiol Rev. 2014; 27:346–370. doi: 10.1128/CMR.00105-13.

Torrone E, Papp J, Weinstock H. Centers for Disease Control and Prevention (CDC). Prevalence of chlamydia trachomatis genital infection among persons aged 14–39 Years-United States, 2007–2012. MMWR Morb Mortal Wkly Rep. 2014; 63:834–838

Satterwhite CL, Torrone E, Meites E, Dunne EF, Mahajan R, Ocfemia MC, et al. Sexually transmitted infections among US women and men: prevalence and incidence estimates, 2008. Sex Transm Dis. 2013; 40:187–93. doi: 10.1097/OLQ.0b013e318286bb53.

Armed Forces Health Surveillance Center Sexually transmitted infections, active component, U.S. Armed Forces, 2000–2012. MSMR. 2013; 20:5–10.

Dielissen PW, Teunissen DA, Lagro-Janssen AL. Chlamydia prevalence in the general population: is there a sex difference? a systematic review. BMC Infect Dis. 2013; 13:534. doi: 10.1186/1471-2334-13-534.

Mishori R, McClaskey EL, WinklerPrins VJ. Chlamydia trachomatis infections: screening, diagnosis, and management. Am Fam Physician. 2012; 86:1127–1132.

Gimenes F, Souza RP, Bento JC, Teixeira JJ, Maria-Engler SS, Bonini MG, et al. Male infertility: a public health issue caused by sexually transmitted pathogens. Nat Rev Urol. 2014; 11:672–687. doi: 10.1038/nrurol.2014.285.

Loza O, Strathdee SA, Martinez GA, Lozada R, Ojeda VD, Staines-Orozco H, et al. Risk factors associated with chlamydia and gonorrhoea infection among female sex workers in two Mexico-USA border cities. Int J STD AIDS. 2010; 21:460–465. doi: 10.1258/ijsa.2010.010018.

Casey PM, Long ME, Marnach ML. Abnormal cervical appearance: what to do, when to worry? Mayo Clin Proc. 2011; 86:147–50. doi: 10.4065/mcp.2010.0512.

Tabrizi SN, Unemo M, Limnios AE, Hogan TR, Hjelmevoll SO, Garland SM, et al. Evaluation of six commercial nucleic acid amplification tests for detection of Neisseria gonorrhoeae and other Neisseria species. J Clin Microbiol. 2011; 49:3610–3615. doi: 10.1128/JCM.01217-11

Esber A, Vicetti Miguel RD, Cherpes TL, Klebanoff MA, Gallo MF, Turner AN. Risk of Bacterial Vaginosis Among Women with Herpes Simplex Virus Type 2 Infection: A Systematic Review and Meta-analysis. J Infect Dis. 2015; 212:8–17. doi: 10.1093/infdis/jiv017.

Allsworth JE, Peipert JF. Severity of bacterial vaginosis and the risk of sexually transmitted infection. Am J Obstet Gynecol. 2011;205:e1–6. doi: 10.1016/j.ajog.2011.02.060

Haddad LB, Wall KM, Kilembe W, Vwalika B, Khu NH, Brill I, Allen S. Bacterial vaginosis modifies the association between hormonal contraception and HIV acquisition. AIDS (London, England). 2018; 32(5), 595–604. http://doi.org/10.1097/QAD.0000000000001741

Gallo MF, Macaluso M, Warner L, Fleenor ME, Hook EW, 3rd, Brill I, et al. Bacterial vaginosis, gonorrhea, and chlamydial infection among women attending a sexually transmitted disease clinic: a longitudinal analysis of possible causal links. Ann Epidemiol. 2012; 22:213–20. doi: 10.1016/j.annepidem.2011.11.005

Abbai NS, Reddy T, Ramjee G. Prevalent bacterial vaginosis infection - a risk factor for incident sexually transmitted infections in women in Durban, South Africa. Int J STD AIDS. 2015.

Balkus J, Anzala O, Kimani J, Schwebkre J, Lee J, Kabare E, et al. Periodic presumptive treatment for vaginal infections may reduce chlamydia and gonorrhea incidence: a secondary analysis from the Preventing Vaginal Infections Trial. Brisbane: World STI and HIV Congress; 2015.

Martínez Martínez W. Actualización sobre vaginosis bacteriana. Revista Cubana de Obstetricia y Ginecología. 2013; 39(4).

Published

2019-10-01

How to Cite

Merchán Villafuerte, K. M., León Granadillo, A. E., Valero Cedeño, N., Quiroz Villafuerte, V. M., & Álava Villafuerte, M. J. (2019). Bacterial vaginosis in women in fertile age: A perspective to analyze. Revista Arbitrada Interdisciplinaria De Ciencias De La Salud. Salud Y Vida, 3(1), 3–31. https://doi.org/10.35381/s.v.v3i6.419