Cerebrospinal fluid as a diagnostic method for meningeal cryptococcosis in HIV patients
DOI:
https://doi.org/10.35381/s.v.v8i2.4111Keywords:
Cryptococcal meningitis, HIV, cerebrospinal fluid, (Source: DeCS)Abstract
Objective: To analyze the clinical history of patients identified with cerebrospinal fluid as a diagnostic method for meningeal cryptococcosis in HIV patients at the Hospital Regional Docente de Ambato - Ecuador. Methods: Descriptive observational, the population was 155 patients of the Hospital Regional Docente de Ambato during the period 2018-2021. Results: There is a significant correlation between altered protein values and CD4 count (<0.01) whose increased values are associated with poor prognosis of meningeal cryptococcosis. Conclusion: Meningeal cryptococcosis in HIV patients remains a highly severe condition, marked by severe neurological symptoms such as headache and seizures, and associated with multifactorial risk factors, including antiretroviral inhibition and altered CD4 levels. Cerebrospinal fluid analysis is confirmed as an essential diagnostic tool, providing key biomarkers that correlate significantly with disease prognosis.
Downloads
References
Islam S, Shukla S, Bajpai VK, Han YK, Huh YS, Kumar A, et al. A smart nanosensor for the detection of human immunodeficiency virus and associated cardiovascular and arthritis diseases using functionalized graphene-based transistors. Biosensors and Bioelectronics 2019;126:792-799. https://doi.org/10.1016/j.bios.2018.11.041
Autenrieth CS, Beck EJ, Stelzle D, Mallouris C, Mahy M, Ghys P. Global and regional trends of people living with HIV aged 50 and over: Estimates and projections for 2000-2020. PLoS One. 2018;13(11):e0207005. https://doi.org/10.1371/journal.pone.0207005
Hurtado JC, Castillo P, Fernandes F, Navarro M, Lovane L, Casas I, et al. Mortality due to Cryptococcus neoformans and Cryptococcus gattii in low-income settings: an autopsy study. Sci Rep. 2019;9(1):1-10. https://doi.org/10.1038/s41598-019-43941-w
Lizarazo J, Castañeda E. Consideraciones sobre la criptococosis en los pacientes con sida. Infectio. 2019;16:94-9. https://n9.cl/ldwfn
Williamson PR, Jarvis JN, Panackal AA, Fisher MC, Molloy SF, Loyse A, et al. Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy. Nat Rev Neurol. 2017;13(1):13-24. https://doi.org/10.1038/nrneurol.2016.167
Rajasingham R, Smith R, Par B. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis. Lancet Infect Dis. 2017;17(8):873-81. https://doi.org/10.1016/S1473-3099(17)30243-8
Zurita J, Denning D, Paz-Miño A, Solís M, Arias L. Serious fungal infections in Ecuador. Eur J Clin Microbiol Infect Dis. 2017;36(6):975-81. https://doi.org/10.1007/s10096-017-2928-5
Pullen MF, Hullsiek KH, Rhein J, Musubire AK, Tugume L, Nuwagira E. Cerebrospinal fluid early fungicidal activity as a surrogate endpoint for cryptococcal meningitis survival in clinical trials. Clin Infect Dis. 2020;71(7):45-9. https://doi.org/10.1093/cid/ciaa016
Abassi M, Bangdiwala A, Nuwagira E. Cerebrospinal fluid lactate as a prognostic marker of disease severity and mortality in cryptococcal meningitis. Clin Infect Dis. 2021;73(9):e3077-82. https://doi.org/10.1093/cid/ciaa1749
Qu J, Jiang J, Lv X. The utility of cerebrospinal fluid white cell count during the prognostic assessment for cryptococcal meningitis patients: a retrospective study. BMC Infect Dis. 2020;20(1):571. https://doi.org/10.1186/s12879-020-05287-x
Genevieve M, Frater J. Post-treatment and spontaneous HIV control. Curr Opin HIV AIDS. 2018;13(5):402-7. https://doi.org/10.1097/COH.0000000000000488
Arias I, Alvarado J, Eras J. Seroconversión de VIH en recién nacidos en la transmisión vertical de madres positivas. J Sci Res. 2020;1-10. https://n9.cl/gvq66
Hurtado-García S, Quintero-Cusgüen P. Criptococosis meníngea. Acta Neurol Colomb. 2021;37(1):90-100.
Mahler A, Rogerio A. Chronic obstructive pulmonary disease (COPD) and asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) are risk factors for cryptococcosis. Open Allergy J. 2020;11:1-7.
Chammard T, Temfack E, Lortholary O. Diagnostic and therapeutic strategies in cryptococcosis: impact on outcome. Mem Inst Oswaldo Cruz. 2018;113(7).
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Diana Alexandra García-Araque, Shirley Vanessa Calero-Carrera, Dayana Abigail Flores-Toapanta, Diego Eduardo Guato-Canchinia
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
CC BY-NC-SA : Esta licencia permite a los reutilizadores distribuir, remezclar, adaptar y construir sobre el material en cualquier medio o formato solo con fines no comerciales, y solo siempre y cuando se dé la atribución al creador. Si remezcla, adapta o construye sobre el material, debe licenciar el material modificado bajo términos idénticos.
OAI-PMH: https://fundacionkoinonia.com.ve/ojs/index.php/saludyvida/oai.
