The pathology of acromegaly

Authors

DOI:

https://doi.org/10.35381/s.v.v8i1.3831

Keywords:

Acromegalia, Pituitary ACTH Hypersecretion, Inappropriate ADH Syndrome, (Source: DeCS)

Abstract

Objective: To analyze the pathology of acromegaly. Method: Descriptive documentary. Conclusion: Acromegaly is a rare condition, its multisystemic nature and its etiopathogenic and pathophysiological bases have allowed important advances in the understanding of the interaction of the somatotropic axis and intermediary metabolism, vascular endothelial damage and tumor genesis mechanisms. At present, the treatment of acromegaly should contemplate not only the surgical, pharmacological and radiotherapeutic aspects of the management of the GH-producing adenoma; careful treatment of associated comorbidities should also be taken into account.

Downloads

Download data is not yet available.

References

Maffezzoni F, Formenti AM. Acromegaly and bone. Minerva Endocrinol. 2018;43(2):168-182. https://doi.org/10.23736/S0391-1977.17.02733-X

Puglisi S, Terzolo M. Hypertension and Acromegaly. Endocrinol Metab Clin North Am. 2019;48(4):779-793. https://doi.org/10.1016/j.ecl.2019.08.008

Weinreb J, Arora S. Acromegaly. N Engl J Med. 2023;388(1):70. https://doi.org/10.1056/NEJMicm2205570

Katznelson L, Laws ER Jr, Melmed S, et al. Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014;99(11):3933-3951. https://doi.org/10.1210/jc.2014-2700

Melmed S. Acromegaly pathogenesis and treatment. J Clin Invest. 2009;119(11):3189-3202. https://doi.org/10.1172/JCI39375

Chanson P, Salenave S. Acromegaly. Orphanet J Rare Dis. 2008;3:17. Published 2008 Jun 25. https://doi.org/10.1186/1750-1172-3-17

Ershadinia N, Tritos NA. Diagnosis and Treatment of Acromegaly: An Update. Mayo Clin Proc. 2022;97(2):333-346. https://doi.org/10.1016/j.mayocp.2021.11.007

Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S. Acromegaly: pathogenesis, diagnosis, and management. Lancet Diabetes Endocrinol. 2022;10(11):804-826. https://doi.org/10.1016/S2213-8587(22)00244-3

Roque J, Marques P. Acromegaly-related cutis verticis gyrata. Growth Horm IGF Res. 2022;66:101497. https://doi.org/10.1016/j.ghir.2022.101497

Ambrosio MR, Gagliardi I, Chiloiro S, et al. Acromegaly in the elderly patients. Endocrine. 2020;68(1):16-31. https://doi.org/10.1007/s12020-020-02206-7

Sharma MD, Nguyen AV, Brown S, Robbins RJ. Cardiovascular Disease in Acromegaly. Methodist Debakey Cardiovasc J. 2017;13(2):64-67. https://doi.org/10.14797/mdcj-13-2-64

Melmed S. Acromegaly. N Engl J Med. 1990;322(14):966-977. https://doi.org/10.1056/NEJM199004053221405

Buchfelder M, Feulner J. Neurosurgical Treatment of Acromegaly. Prog Mol Biol Transl Sci. 2016;138:115-139. https://doi.org/10.1016/bs.pmbts.2015.11.002

Jallad RS, Bronstein MD. Acromegaly in the elderly patient. Arch Endocrinol Metab. 2019;63(6):638-645. https://doi.org/10.20945/2359-3997000000194

Gadelha MR, Gadelha AC, Kasuki L. New Treatments for Acromegaly in Development. J Clin Endocrinol Metab. 2024;109(4):e1323-e1327. https://doi.org/10.1210/clinem/dgad568

Published

2024-02-01

How to Cite

Estévez-Domínguez, D. S., López-Haro, C. N., Bermeo-Ávalos, A. N., & Altamirano, O. (2024). The pathology of acromegaly. Revista Arbitrada Interdisciplinaria De Ciencias De La Salud. Salud Y Vida, 8(1), 793–799. https://doi.org/10.35381/s.v.v8i1.3831

Issue

Section

Original breve