The pathology of acromegaly
DOI:
https://doi.org/10.35381/s.v.v8i1.3831Keywords:
Acromegalia, Pituitary ACTH Hypersecretion, Inappropriate ADH Syndrome, (Source: DeCS)Abstract
Objective: To analyze the pathology of acromegaly. Method: Descriptive documentary. Conclusion: Acromegaly is a rare condition, its multisystemic nature and its etiopathogenic and pathophysiological bases have allowed important advances in the understanding of the interaction of the somatotropic axis and intermediary metabolism, vascular endothelial damage and tumor genesis mechanisms. At present, the treatment of acromegaly should contemplate not only the surgical, pharmacological and radiotherapeutic aspects of the management of the GH-producing adenoma; careful treatment of associated comorbidities should also be taken into account.
Downloads
References
Maffezzoni F, Formenti AM. Acromegaly and bone. Minerva Endocrinol. 2018;43(2):168-182. https://doi.org/10.23736/S0391-1977.17.02733-X
Puglisi S, Terzolo M. Hypertension and Acromegaly. Endocrinol Metab Clin North Am. 2019;48(4):779-793. https://doi.org/10.1016/j.ecl.2019.08.008
Weinreb J, Arora S. Acromegaly. N Engl J Med. 2023;388(1):70. https://doi.org/10.1056/NEJMicm2205570
Katznelson L, Laws ER Jr, Melmed S, et al. Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014;99(11):3933-3951. https://doi.org/10.1210/jc.2014-2700
Melmed S. Acromegaly pathogenesis and treatment. J Clin Invest. 2009;119(11):3189-3202. https://doi.org/10.1172/JCI39375
Chanson P, Salenave S. Acromegaly. Orphanet J Rare Dis. 2008;3:17. Published 2008 Jun 25. https://doi.org/10.1186/1750-1172-3-17
Ershadinia N, Tritos NA. Diagnosis and Treatment of Acromegaly: An Update. Mayo Clin Proc. 2022;97(2):333-346. https://doi.org/10.1016/j.mayocp.2021.11.007
Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S. Acromegaly: pathogenesis, diagnosis, and management. Lancet Diabetes Endocrinol. 2022;10(11):804-826. https://doi.org/10.1016/S2213-8587(22)00244-3
Roque J, Marques P. Acromegaly-related cutis verticis gyrata. Growth Horm IGF Res. 2022;66:101497. https://doi.org/10.1016/j.ghir.2022.101497
Ambrosio MR, Gagliardi I, Chiloiro S, et al. Acromegaly in the elderly patients. Endocrine. 2020;68(1):16-31. https://doi.org/10.1007/s12020-020-02206-7
Sharma MD, Nguyen AV, Brown S, Robbins RJ. Cardiovascular Disease in Acromegaly. Methodist Debakey Cardiovasc J. 2017;13(2):64-67. https://doi.org/10.14797/mdcj-13-2-64
Melmed S. Acromegaly. N Engl J Med. 1990;322(14):966-977. https://doi.org/10.1056/NEJM199004053221405
Buchfelder M, Feulner J. Neurosurgical Treatment of Acromegaly. Prog Mol Biol Transl Sci. 2016;138:115-139. https://doi.org/10.1016/bs.pmbts.2015.11.002
Jallad RS, Bronstein MD. Acromegaly in the elderly patient. Arch Endocrinol Metab. 2019;63(6):638-645. https://doi.org/10.20945/2359-3997000000194
Gadelha MR, Gadelha AC, Kasuki L. New Treatments for Acromegaly in Development. J Clin Endocrinol Metab. 2024;109(4):e1323-e1327. https://doi.org/10.1210/clinem/dgad568
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Danae Solange Estévez-Domínguez, Camila Nicol López-Haro, Alisson Nicol Bermeo-Ávalos, Olivia Altamirano

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
CC BY-NC-SA : Esta licencia permite a los reutilizadores distribuir, remezclar, adaptar y construir sobre el material en cualquier medio o formato solo con fines no comerciales, y solo siempre y cuando se dé la atribución al creador. Si remezcla, adapta o construye sobre el material, debe licenciar el material modificado bajo términos idénticos.
OAI-PMH: https://fundacionkoinonia.com.ve/ojs/index.php/saludyvida/oai.



