Vitamin D: An adjuvant therapy in the management of covid-19

Authors

DOI:

https://doi.org/10.35381/s.v.v8i15.3199

Keywords:

Vit-D, COVID-19, supplementation, therapy, (Source: DeCS)

Abstract

Objective: to determine how Vit-D acts at the immune system level reducing the risk of severity by COVID-19. Methods: Descriptive observational study. Results and conclusions: The defensive role of Vit-D against respiratory system related infections is demonstrated in clinical trials. Supplementation is suggested to maintain optimal circulating levels in the body. There is evidence of a significant association between Vit-D insufficiency/deficiency and susceptibility to COVID-19 and its severity.  Therefore, Vit-D supplementation is suggested to maintain a serum concentration greater than 30 ng/mL to reduce the risk of SARS-CoV-2 infection and its consequences.

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References

Mansur JL, et al. Vitamin D high doses supplementation could represent a promising alternative to prevent or treat COVID-19 infection. Clin Investig Arterioscler. 2020;32(6):267-277. https://doi.org/10.1016/j.arteri.2020.05.003

Chiodini I, et al. Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes. Front. Public Health, 2021;9:736665. https://doi.org/10.3389/fpubh.2021.736665

Cutolo M, Paolino S, Smith V. Evidences for a protective role of vitamin D in COVID-19. RMD Open 2020;6:e001454. http://dx.doi.org/10.1136/rmdopen-2020-001454

Mejía-Zambrano H. Efectos de la Vitamina D sérico y suplemento en pacientes infectados por la COVID-19 [Effects of serum vitamin D and supplement in COVID-19 infected patients]. (2022). Rev. Peru. Investig. Salud. 2022;6(1):33-42. https://doi.org/10.35839/repis.6.1.1141

Seijo M., Oliveri B. Importancia de la Vitamina D en la época del COVID-19 [Importance of Vit-D in the time of COVID-19]. Actual. Osteol 2020;16(2). https://n9.cl/s1bq03

Niño-Parra DA, Poveda-Espinosa E, Mora-Plazas M. Vitamina D, sus posibles efectos en la función inmune y la respuesta ante la COVID-19: una revisión sistemática exploratoria [Vit-D, its possible effects on immune function and response to COVID-19: an exploratory systematic review]. Rev. Nutr. Clin. Metab. 2021;4(3). https://doi.org/10.35454/rncm.v4n3.278

Díez J. El sistema endocrino de la Vitamina D: fisiología e implicaciones clínicas [The vitamin D endocrine system: physiology and clinical significance]. Revista española de cardiología. 2022;2(C):1-7 https://doi.org/10.1016/S1131-3587(22)00005-X

Palacios-Cruz M, et al. COVID-19, una emergencia de salud pública mundial [COVID-19, a worldwide public health emergency]. Rev Clin Esp. 2020. https://doi.org/10.1016/j.rce.2020.03.001

Díaz-Castrillón FJ, Toro-Montoya AI. SARS-CoV-2/COVID-19: el virus, la enfermedad y la pandemia [SARS-CoV-2/COVID-19: The virus, the disease and the pandemic]. Medicina & Laboratorio 2020;24:183-205. https://docs.bvsalud.org/biblioref/2020/05/1096519/covid-19.pdf

Hernández A, Esquer Z, Marcelin J. COVID-19 Pathogenesis and Clinical Manifestations. Infectious Disease Clinics of North America. 2022;36(2):231-249. https://doi.org/10.1016/j.idc.2022.01.003

Mesquita RdR, Silva-Junior LCF, Santos-Santana FM et al. Clinical manifestations of COVID-19 in the general population: systematic review. Wiener klinische Wochenschrift. 2021;133(7-8):377–382. https://doi.org/10.1007/s00508-020-01760-4

Bleizgys A. (2020). Vitamin D and COVID‐19: It is time to act. Int J Clin Pract. 2021;75(3):e13748. https://doi.org/10.1111/ijcp.13748

Ghelani D, Alesi S, Mousa A. Vitamin D and COVID-19: An Overview of Recent Evidence. Int. J. Mol. Sci. 2021;22:10559. https://doi.org/10.3390/ijms221910559

Williams SE. Vitamin D supplementation: Pearls for practicing clinicians. Cleveland Clinic journal of medicine, 2022;89(3):154–160. https://doi.org/10.3949/ccjm.89a.21021

Aygun H. Vitamin D may protect against multiple organ damage caused by COVID-19. Bratisl Lek Listy. 2020;121(12):870-7. https://doi.org/10.4149/BLL_2020_143

Rastogi A et al., Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study. Postgraduate Medical Journal. 2022;98(1156):87–90. https://doi.org/10.1136/postgradmedj-2020-139065

Tomaszewska A, Rustecka A, Lipińska-Opałka A, et al. The Role of Vitamin D in COVID-19 and the Impact of Pandemic Restrictions on Vitamin D Blood Content. Front. Pharmacol. 2022;13,836738. https://doi.org/10.3389/ fphar.2022.836738

Bae JH, Choe HJ, Holick MF et al. Association of vitamin D status with COVID-19 and its severity. Rev Endocr Metab Disord 2022;23:579–599. https://doi.org/10.1007/s11154-021-09705-6

Lakkireddy M, Gadiga SG, Malathi RD, et al. Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease. Scientific reports. 2021;11(1):10641. https://doi.org/10.1038/s41598-021-90189-4

Tan CW, Ho LP, Kalimuddin S et al. Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19). Nutrition. 2020;79-80:111017. https://doi.org/10.1016/j.nut.2020.111017

Alcala-Diaz JF, Limia-Perez L, Gomez-Huelgas R, et al. Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study. Nutrients. 2021;13(6), 1760. https://doi.org/10.3390/nu13061760

Murai IH, Fernandes AL, Sales LP, et al. Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial. JAMA. 2021;325(11):1053–1060. https://doi.org/10.1001/jama.2020.26848

Sabico S, Enani MA, Sheshah E, et al. Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial. Nutrients. 2021;13:2170. https://doi.org/10.3390/nu13072170

Ohaegbulam KC, Swalih M, Patel P, et al. Vitamin D Supplementation in COVID-19 Patients: A Clinical Case Series. American journal of therapeutics. 2020;27(5):e485–e490. https://doi.org/10.1097/MJT.0000000000001222

Ducharme FM, Tremblay C, Golchi S, et al. Prevention of COVID- 19 with oral vitamin D supplemental therapy in essential healthcare teams (PROTECT): protocol for a multicentre, triple- blind, randomised, placebo- controlled trial. BMJ Open 2023;13:e064058. https://doi.org/10.1136/bmjopen-2022-064058

Moukayed M. A Narrative Review on the Potential Role of Vitamin D3 in the Prevention, Protection, and Disease Mitigation of Acute and Long COVID-19. Curr Nutr Rep 2023;12,215–223. https://doi.org/10.1007/s13668-023-00471-2

Ahsan N et al. Mechanistic Insight into the role of Vitamin D and Zinc in Modulating Immunity Against COVID-19: A View from an Immunological Standpoint. Biol Trace Elem Res. 2023. https://doi.org/10.1007/s12011-023-03620-4

Quesada-Gomez JM, et al. Vitamin D Endocrine System and COVID-19: Treatment with Calcifediol. Nutrients. 2022,14:2716. https://doi.org/10.3390/ nu14132716

Argano C, Mallaci-Bocchio R, Natoli G et al. Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis. Pharmaceuticals. 2023;16(1):130. https://doi.org/10.3390/ph16010130

Ashique S, Gupta K, Gupta G, et al. Vitamin D-A prominent immunomodulator to prevent COVID‐19 infection. Int J Rheum Dis. 2023;26(1):13–30. http://dx.doi.org/10.1111/1756-185x.14477

Published

2024-01-01

How to Cite

Yanez-Chicaiza, E. Y., & Galarza-Galarza, C. K. (2024). Vitamin D: An adjuvant therapy in the management of covid-19. Revista Arbitrada Interdisciplinaria De Ciencias De La Salud. Salud Y Vida, 8(15), 65–79. https://doi.org/10.35381/s.v.v8i15.3199

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Original breve