Molecular basis and genetics in oral cancer
DOI:
https://doi.org/10.35381/s.v.v5i1.1623Keywords:
Mouth Neoplasms, radiotherapy, diagnostic imaging. (Source, DeCS).Abstract
Objective: To know the genetic and molecular basis of oral cancer. Method: Documentary type, through a search of articles in databases such as: Pubmed, Scielo, Dentistry and Oral, Science Direct. Results: Chromosomal deletions and mutations in chromosomes 3p, 9p, 17p and 13q have been observed; mutations in p53 have been described. Overexpression of cyclin D1 is possible; there is also often overexpression of the epidermal growth factor receptor. Conclusion: The mechanism of cell death, especially apoptosis, is a fundamental and critical process which determines the homeostasis of the body, generally when there is a failure at the level of this process in any of its stages an injury will occur.
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References
García-García V., Bascones Martínez A. Update in oral cancer. Av Odontoestomatol [Internet]. 2009; 25(5): 239-248.
Betancourt-Gambino J. Cáncer en pacientes viviendo con VIH/sida [Cancer in patients living with HIV/AIDS]. Rev Cubana Med Gen Integr [Internet]. 2018; 34(2): 1-9.
Cameron JE, Hagensee M. HPV-Associated Oropharyngeal Cancer in the HIV/AIDS Patient. Cancer Treat Res. 2019;177:131-181. doi:10.1007/978-3-030-03502-0_6
McNally GA. HIV and Cancer: An Overview of AIDS-Defining and Non-AIDS-Defining Cancers in Patients With HIV. Clin J Oncol Nurs. 2019;23(3):327-331. doi:10.1188/19.CJON.327-331
Spano JP, Veyri M, Gobert A, et al. Immunotherapy for cancer in people living with HIV: safety with an efficacy signal from the series in real life experience. AIDS. 2019;33(11):F13-F19. doi:10.1097/QAD.0000000000002298
Merlo LM, Pepper JW, Reid BJ, Maley CC. Cancer as an evolutionary and ecological process. Nat Rev Cancer. 2006;6(12):924-935. doi:10.1038/nrc2013
García-García V, González-Moles MA, Bascones Martínez A. Bases moleculares del cáncer oral: Revisión bibliográfica [Molecular basis of oral cancer: literature review.]. Av Odontoestomatol [Internet]. 2005 ; 21(6): 287-295.
Gallegos-Villanueva MJ, Chimenos-Küstner E, López-López J, Roselló-Llabrés X. Cancerización de campo: revisión del concepto [Field cancerization: revision of the concept]. Av Odontoestomatol [Internet]. 2007; 23(1): 35-44.
Waldum HL, Fossmark R. Types of Gastric Carcinomas. Int J Mol Sci. 2018;19(12):4109. Published 2018 Dec 18. doi:10.3390/ijms19124109
Dai L, Zhao T, Bisteau X, et al. Modulation of Protein-Interaction States through the Cell Cycle. Cell. 2018;173(6):1481-1494.e13. doi:10.1016/j.cell.2018.03.065
Kartal-Yandim M, Adan-Gokbulut A, Baran Y. Molecular mechanisms of drug resistance and its reversal in cancer. Crit Rev Biotechnol. 2016;36(4):716-726. doi:10.3109/07388551.2015.1015957
Karimian A, Ahmadi Y, Yousefi B. Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage. DNA Repair (Amst). 2016;42:63-71. doi:10.1016/j.dnarep.2016.04.008
Fricker M, Tolkovsky AM, Borutaite V, Coleman M, Brown GC. Neuronal Cell Death. Physiol Rev. 2018;98(2):813-880. doi:10.1152/physrev.00011.2017
Viallard C, Larrivée B. Tumor angiogenesis and vascular normalization: alternative therapeutic targets. Angiogenesis. 2017;20(4):409-426. doi:10.1007/s10456-017-9562-9
Czarnecka AM, Niedzwiedzka M, Porta C, Szczylik C. Hormone signaling pathways as treatment targets in renal cell cancer (Review). Int J Oncol. 2016;48(6):2221-2235. doi:10.3892/ijo.2016.3460
Ramjiawan RR, Griffioen AW, Duda DG. Anti-angiogenesis for cancer revisited: Is there a role for combinations with immunotherapy?. Angiogenesis. 2017;20(2):185-204. doi:10.1007/s10456-017-9552-y
Sajib S, Zahra FT, Lionakis MS, German NA, Mikelis CM. Mechanisms of angiogenesis in microbe-regulated inflammatory and neoplastic conditions. Angiogenesis. 2018;21(1):1-14. doi:10.1007/s10456-017-9583-4
Wong T, Wiesenfeld D. Oral Cancer. Aust Dent J. 2018;63 Suppl 1:S91-S99. doi:10.1111/adj.12594
Ter Huurne M, Peng T, Yi G, van Mierlo G, Marks H, Stunnenberg HG. Critical Role for P53 in Regulating the Cell Cycle of Ground State Embryonic Stem Cells. Stem Cell Reports. 2020;14(2):175-183. doi:10.1016/j.stemcr.2020.01.001
Baker SJ, Vogelstein B. p53: a tumor suppressor hiding in plain sight. J Mol Cell Biol. 2019;11(7):536-538. doi:10.1093/jmcb/mjz068
Weinhold N, Ashby C, Rasche L, et al. Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma. Blood. 2016;128(13):1735-1744. doi:10.1182/blood-2016-06-723007
Feng LY, Chen CX, Li L. Hypermethylation of tumor suppressor genes is a risk factor for poor prognosis in ovarian cancer: A meta-analysis. Medicine (Baltimore). 2019;98(8):e14588. doi:10.1097/MD.0000000000014588
Schoenberg M, Cairns P, Brooks JD, et al. Frequent loss of chromosome arms 8p and 13q in collecting duct carcinoma (CDC) of the kidney. Genes Chromosomes Cancer. 1995;12(1):76-80. doi:10.1002/gcc.2870120115
Khurshid Z, Zafar MS, Khan RS, Najeeb S, Slowey PD, Rehman IU. Role of Salivary Biomarkers in Oral Cancer Detection. Adv Clin Chem. 2018;86:23-70. doi:10.1016/bs.acc.2018.05.002
Varela-Centelles P, Castelo-Baz P, Seoane-Romero J. Oral cancer: Early/delayed diagnosis. Br Dent J. 2017;222(9):643. doi:10.1038/sj.bdj.2017.380
Chattopadhyay I, Verma M, Panda M. Role of Oral Microbiome Signatures in Diagnosis and Prognosis of Oral Cancer. Technol Cancer Res Treat. 2019;18:1533033819867354. doi:10.1177/1533033819867354
Mateo-Sidrón Antón M.C., Somacarrera Pérez M.L. Cáncer oral: genética, prevención, diagnóstico y tratamiento. revisión de la literatura [Oral cancer: Genetics, prevention, diagnosis and treatment. Literature review]. Av Odontoestomatol [Internet]. 2015; 31(4): 247-259. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0213-12852015000400002&lng=es. https://dx.doi.org/10.4321/S0213-12852015000400002.
Figueroa-Sánchez M, Núñez-Atahualpa L, Hernández-Zúñiga M, et al. Evaluación clínica y ultrasonográfica de la glándula tiroides en pacientes con artritis reumatoide [Clinical and ultrasonographic evaluation of the thyroid gland in patients with rheumatoid arthritis]. Gac Med Mex. 2018;154(4):432-437. doi:10.24875/GMM.18003556
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